Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in Koreans
Journal of Korean Medical Science
; : 495-498, 2005.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-53820
Biblioteca responsável:
WPRO
ABSTRACT
1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), which is the biologically active form of vitamin D, has anti-inflammatory effects and can prevent experimental Parkinson's disease (PD). 1,25(OH)2D3 exerts most of its actions only after it binds to its specific nuclear receptors. Eighty-five Korean patients with PD and 231 unrelated healthy individuals were evaluated to determine if vitamin D receptor gene (VDRG) BsmI polymorphisms were markers for the susceptibility to PD in Korean patients. Each polymorphism was detected using polymerase chain reaction (PCR)-based restriction analysis. In addition, the relationship between the BsmI polymorphisms and the clinical manifestations of PD was evaluated. Overexpression of the b allele (91.2 vs. 85.7%; p=0.069) and homozygote bb (84.7 vs. 72.7%; p=0.043) was found in the PD patients compared with the controls. These results show for the first time an association between PD and a VDRG polymorphism, which might be involved in the pathogenesis of PD, or in the linkage disequilibrium of the VDRG to another pathogenic gene locus.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Polimorfismo Genético
/
DNA
/
Desoxirribonucleases de Sítio Específico do Tipo II
/
Desequilíbrio de Ligação
/
Receptores de Calcitriol
/
Alelos
/
Frequência do Gene
/
Genótipo
/
Coreia (Geográfico)
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2005
Tipo de documento:
Artigo