Survivin ,P21~(WAF1/CIP1),Cyclin D1 proteins expression in cervical carcinoma:correlations with recurrence of early stage cervical cancer of the uterus / 中国癌症杂志
China Oncology
; (12)2000.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-538913
Biblioteca responsável:
WPRO
ABSTRACT
Purpose:
To study the expression of Survivin,P21 WAF1/CIP1 and CyclinD1 proteins in cervical carcinoma and to investigate their relation to recurrence of early stage cervical cancer of the uterus.Methods:
Using streptavidin-biotin peroxidase (sp) method,we examined the protein expression of Survivin, P21 WAF1/CIP1 and Cyclin D1 in 55 cervical carcinomas (45 cervical squamous carcinomas and 10 cervical adenocarcinomas ) and 10 normal cervical tissues.Results:
① The positive rates of Survivin,Cyclin D1,P21 WAF1/CIP1 were 0,10.0%,20.0% in normal cervical tissue,and 68.9%,51.1%,57,8% in cervical squamous carcinomas,and 60.0%,90.0%,80.0% in cerrical adenocarcinomas respectively. There were significant differences in the positive results of Survivin,CyclinD1,P21 WAF1/CIP1 between normal cervical tissue and cervical cancer ( P 0.05).③The coexpression of Survivin with P21 WAF1/CIP1 or CyclinD1 were both associated with higher tumor grade( P
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Oncology
Ano de publicação:
2000
Tipo de documento:
Artigo