The effect of TNP-470 treatment on ascitic-fluid type hepatocarcinoma H22 / 肿瘤研究与临床

ABSTRACT

Objective To study the effect of TNP-470 treatment on ascitic hepatocarcinoma H22 and potential mechanisms. Methods The experimental approaches employed in the study included in vitro assays of cell proliferation and migration, and in vivo ascitic hepatocarcinoma mouse model. Results In vitro, TNP-470 inhibited cell proliferation of both H22 and human microvascular endothelial cell HMEC. Furthermore, TNP-470 inhibited HMEC migrations. In vivo, TNP-470 treatment significantly improved the life quality of the tumor-loaded mice, including lessen the ascitic effasion, decreased tumor cell viability, lessen the eye blindness, and prolonged the life-span. Conclusion These observations demonstrate that TNP-470 would be an effective drug for treatment of ascitic-fluid type hepatocarcinoma mice.