THE ANTAGONISTIC EFFECT OF SODIUM COBALTINITRITE BY INTRAMUSCULAR INJECTION ON CYANIDE INTOXICATION / 第二军医大学学报

ABSTRACT

This paper reports the antagonistic effect of sodium cobaltinitrite by intramus-cular injection on cyanide intoxication. The sodium cobaltinitrite (10%) dime-thylsulfoxide solution was administrated intramuscularly when convulsion appeared in dogs 5-10 min after intramuscular injection of potassium cyanide(1-2.5LD) or 15s after inhalation of hydrocyanic acid (2LD50). The animal survival rate was 20/22 and 8/10, respectively. The cats intoxicated by lethal dose of hydrocyanic acidinhalation were given sodium cobaltinitrite intramuscularly, and a good therapeutic effect was also obtained.This study provides an experiment basis in search of an antagonist of cyanide, which takes effect rapidly, is administrated conveniently and is suitable rescue in the field, with a convenient administrating means.