The effect of BMSCs/coral composite strengthened by titanium mesh in the repair of mandibular defects / 实用口腔医学杂志

ABSTRACT

Objective:To observe the effects of bone marrow stromal cells(BMSCs)/coral composite strengthened by titanium mesh in the repair of mandibular defects. Methods:The rabbits' BMSCs were cultured and induced in vitro, and then were combined with coral to form the BMSCs/coral composite, which were implanted into the left mandibular defect in the size of 15 mm?8 mm in 16 rabbits. Titanium mesh was used to strengthen and fix the composites. Coral implant was used as the control in the right mandibular defect.Six and twelve weeks after operation, X-ray observation and histological examination were employed to assess the status of bone formation. Results:In the experimental group, new bone formation was found by radiography and the histological examination 6 weeks after operation. 12 weeks after operation woven bone and lamellar bone were observed in the implanted area and the bone defects were repaired, coral was disappeared, titanium was integrated with surrounding bone tissue. In the control group 12 weeks after operation the bone defects were filled by fibrous tissue, coral was disappeared. Conclusion:Titanium /BMSCs/coral composites can repair mandibular defects effectively.