Correlation between Contrast-enhanced MRI Features and the mRNA Expression of VEGF and bFGF in Pituitary Adenomas / 实用放射学杂志

ABSTRACT

Objective To investigate the correlation between mRNA expression of VEGF,bFGF and dynamic contrast-enhancedT_1-weighted MRI together with conventional MRI features in pituitary adenomas.Methods Conventional MRI and gadolinium-enhanced dynamic Turbo-FLASH imaging was performed preoperatively in 30 patients with histologically verified pituitary adenoms.VEGF and bFGF mRNA expression were determined in pituitary adenomas by using comparative reverse transcription-polymerase chain reaction(RT-PCR) in all patients.The correlation between mRNA expression of VEGF/bFGF and dynamic contrast-enhanced and conventional MRI featureswere studied.Results Significant difference in VEGF and bFGF mRNA expression was found among pituitary adenomas according to different signal intensity-time curve(SI-TC) type(P