Prolongation of renal allografts survival in rats by tolerogenic recipient dendritic cells loaded with donor renal antigen / 中华器官移植杂志
Chinese Journal of Organ Transplantation
; (12)1996.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-542569
Biblioteca responsável:
WPRO
ABSTRACT
Objective To study the influence of recipient tolerogenic dendritic cells(DCs) loaded with donor renal antigen on renal allografts survival in rats.Methods Bone marrow derived DCs of Lewis rats were loaded with antigens from donor kidney of BN rats and transferred with AdvCTLA-4Ig to generate tolerogenic DCs.The tolerogenic DCs were injected into the Lewis recipient 24 h before BN→Lewis kidney transplantation(treatment group).Survival time of renal allografts was observed and splenic cell reaction of the recipients to donors and the third party antigens were assayed by means of MTT on the 20~(th)postoperative day.Results Survival time of renal allografts in treatment group was prolonged significantly as compared with controls ((62.1)?(13.7) days vs(8.6)?(0.9) days,P
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Organ Transplantation
Ano de publicação:
1996
Tipo de documento:
Artigo