Relationship between the expression of EGFR,C-erbB-2 proteins and the lung metastatic potential of salivary adenoid cystic carcinoma cell lines / 实用口腔医学杂志
Journal of Practical Stomatology
; (6)2001.
Article
em Zh
| WPRIM
| ID: wpr-543216
Biblioteca responsável:
WPRO
ABSTRACT
Objective:To investigate the expressions of epidermal growth factor receptor(EGFR) and C-erbB-2 in two salivary adenoid cystic carcinoma cell lines with different metastatic potential. Methods:Salivary adenoid cystic carcinoma SACC-83 cell line and its lung metastatic cell line SACC-LM were cultured in vitro, their cytoplasm and membrane samples were extracted, and the expressions of EGFR and C-erbB-2 were detected by Western blot, the results were quantitatively analyzed by FluorChem V2.0 software.Results:EGFR expression level in cell membrane was higher than that in cytoplasm(P0.05) in both cell lines.Conclusion:Higher EGFR expression in cytoplasm and higher C-erbB-2 expression may be related to the metastatic potential of SACC-LM cells.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Practical Stomatology
Ano de publicação:
2001
Tipo de documento:
Article