Effect of Potassium Iodate on Anti-oxidative Capability of Blood in Rats / 环境与健康杂志

ABSTRACT

Objective To study the effect of different dosage KIO3 on anti-oxidative capability of the blood.Methods The Wistar rats were randomly divided into 6 groups and given KIO3 through food at different dosages,low iodide(LI),normal iodide(NI),5 fold high iodide(5HI),10 fold high iodide(10HI),50 fold high iodide(50HI)and 100 fold high iodide(100HI).3,6 and 12 months later,the rats were sacrificed and blood glutathione peroxidase(GPx)activity,superoxide dismutase(SOD)activity and malondialdehyde(MDA)content were determined.Results After 3,6 and 12 months of treatment,the GPx activity in LI group was significantly lower than that in NI group.Furthermore,after 12 months of low iodide intake,the SOD activity in LI group was higher than that in NI group.The GPx activity in 100HI group was lower than that in NI group after 3 months of administration,but no difference was seen between these two groups after 6 and 12 months of treatment.No difference was found in the GPx activity of NI group and those of 5HI,10HI and 50HI groups.The SOD activity in 50HI and 100HI groups was higher than that in NI group after 12 months of administration.There was no difference in MDA content among NI group and 4 high iodide groups.Conclusion Low iodide intake may damage the anti-oxidative capability of blood in normal rats.Blood has a strong anti-oxidative ability and compensative capabilities to compete with high iodate intake.