Toxic Effects of Rotenone on Substantia Nigra of Rats / 环境与健康杂志
Journal of Environment and Health
; (12)1989.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-545097
Biblioteca responsável:
WPRO
ABSTRACT
Objective To study the toxic effects of rotenone on substantia nigra of rats. Methods Rotenone was given subcutaneously once a day during 28 days. Substantia nigra was dissected. Morphology of dopamine neuron, synapse and myelin sheath were observed. SOD and GSH-Px activity were assayed; MDA and GSH contents were measured. Results Autonomic activities of rats decreased, similar to Parkinson's Symptoms. Morphology of dopamine neuron changed, synapse structures were abnormal, synapse vesicals increased and myelin sheath degenerated. MDA content increased (P
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Environment and Health
Ano de publicação:
1989
Tipo de documento:
Artigo