Effects of Aluminium Exposure on ?-CaMKⅡ in Hippocampus of Lactational Rats / 环境与健康杂志
Journal of Environment and Health
; (12)2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-545649
Biblioteca responsável:
WPRO
ABSTRACT
Objective To explore the mechanism of aluminum-induced damage of learning and memory by studying the change of calcium-calmodulin-dependent protein kinase Ⅱ(CaMKⅡ) in the hippocampus of lactational rats. Methods Three groups of clean pregnant Wistar rats (120-200 g) were randomly divided into 3 groups. On the first day of parturition, the dams of two groups were given 0.3% and 0.6% AlCl3 through drinking water and terminated on the weaning day (21 days). Western blot was used to determine the content and activity of ?-CaMKⅡ. Results The aluminum levels in the blood and brain of aluminum-treated rats were obviously higher than that in the control (P
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Environment and Health
Ano de publicação:
2007
Tipo de documento:
Artigo