EFFECTS OF HEPATOCELLULAR TRANSPLANTATION ON ACUTE LIVER FAILURE IN RATS / 第二军医大学学报

ABSTRACT

In this study, acute liver failure was induced in rats by d-galactosamine (D-GalN) injection. Intraperitoneal injection,24 h later, of viable syngeneic hepatocytes apparently increased the survival rate of these animals (48%), while transplantation of non-viable hepatocytes was ineffective and even showed a certain degree of clotting disorders.A microscopical observation of the liver specimens and estimation of DNA synthesis cy 3H-TdR suggest that viable hepatocellular transplantation may minimize the hepatic injury and promote hepatic cell regeneration.