Dynamic Changes of Platelet Aggregation and Serum Fibrin Derived Products after Smoke Inhalation Injury in Rabbits / 第三军医大学学报

ABSTRACT

The dynamic changes of the maximal platelet aggregation rate (PARm) and serum fibrin derived products (FDP) after smoke inhalation injury in rabbits were observed. The pathological changes of the lung tissues and lung water content were also studied after the animals were killed. It was found that PARm increased in the 6th and 22nd postburn hours(PBH), the platelet count decreased progressively right after injury, and FDP increased in the 6th and 24th PBH. In addition, there were alveolar edema and hemorrhage with deposition of fibrin in the lung parenchyma. In the lumen of some small pulmonary vessels, platelet aggregation with evacuation of their granules was demonstrated, which implies there is release of certain chemical mediators. The lung water content increased apparently. Clinical symptoms such as difficulty in bretahing. rales over the chest, etc developed along with the changes of platelets and FDP.On the basis of the analysis of the results listed above, it is proposed that the changes of platelets and FDP may play an important role in the development of pulmonary damage after smoke inhalation.