EFFECTS OF SILYBIN ON ISOLATED RABBIT PORTAL VEIN AND THORACIC AORTA / 第二军医大学学报

ABSTRACT

On isolated rabbit portal vein preparations, silybin shifted the cumulative concentration-response curves for NA, KCl, and CaCl2 to right, and depressed their maximal responses with an IC60 of 0.04, 0.43, and 0.07 mmol/L, respectively. On thoracic aorta, the cumulative concentration-responses induced by KCl and CaCl2 were inhibited by silybin with an IC50 of 41.4 and 1.4 mmol/L,respectively, whereas the NA induced responses were not affected. The results suggest that silybin may have a weak calcium antagonistic effect, especially on portal vein.