Histochemical and ultrastructural study of early gastric carcinoma and peri-cancerous lesions——An investigation of histogensin of early gastrtic carcinoma / 第三军医大学学报

ABSTRACT

The ultrastructural and mucinhistochcmical study of 28 cancerous lesions is reported.They respectively associated with atrophic gastritis in 85.93%,intestinal metaplasia in 81.82%,and dysplasia in 78.59%.So high incidence suggests a close relationship between the lesions and the development of early gastric carcinoma,By means of AB-PAS and HID staining the cancerous lesions of intestinal type 20(71.42%),gaslric type 5(17.85%) and mixed type 3(10.71%) show that intestinal metaplasia of colonic type seems closely relate to carcinoma.Studying the specimens from 6 gastric carcinomas of different histological type and pcricanccrous lesions by electron microscopy,there arc microvilli of different sizes and densities on their free surfaces in the cancer cells with granule formation.Some of the signet ring carcinoma cells contain goblet type mucous granules.The ultrastructuc of severe dysplasia closely resembles,gastric cancer cells.