THE PREVENTIVE EFFECTS OF CHLOROQUINE ON LUNG EDEMA INDUCED BY ACUTE CANINE PANCREATITIS / 第二军医大学学报

ABSTRACT

Actute canine hemorrhagic pancreatitis was induced by injection of autobile 1 ml/ kg into the main pancreatic duct, and the effects of pretrcatment with phospholipase A2 inhibitor-chloroquine on pulmonary edema were observed.The results revealed that in animals with acute pancreatitis, lung index and wet to dry lung weight ratio increased significantly, and pulmonary blood volume and extravascular water volume also increased obviously.There were also increments of protein and cell contents in bronchoalveolar lavage fluid.Cell sorting showed significantly decreased percentage of macrophages, and increased percentage of PMN and type n pneumocytes.Pretreat-ment with chloroquine prevented the development of pulmonary edema and the appreciably increased percentage of PMN.This experiment suggests that in acute canine pancreatitis, phospholipase AI may play an important part in pulmonary edema, and chloroquine has potential clinical value in the treatment.