EFFECT OF POLLEN ELEMENT FROM BUCKWHEAT, AND ISOCORYDINE ON THE GERBILS SUBJECTED TO CEREBRAL ISCHEMIA AND THEN REPERFUSION / 中国药理学通报

ABSTRACT

After 45 min ligation of the gerbils' bilateral carotid arteries and then 24h reperfusion,the effects of water soluble Pollen flavone element from buckwheat, Isocorydine on the stroke index of 45 min cerebral ischemia followed by reperfusion 6h and the mortality of reperfusion 24h were evaluated .The results indicated that pollen element from buckwheat could decrease the stroke index and mortality rate dramatically, while Isocorydine had no effects.It was speculated that the beneficial effects of pollen element from buckwheat on cerebral damage following ischemia with reperfusion might be due to its depressing effect on the metabolism of free radicals.