Excitotoxic Cell Death in Cultured Retinal Neurons
Journal of the Korean Ophthalmological Society
; : 1987-1999, 1997.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-55063
Biblioteca responsável:
WPRO
ABSTRACT
We examined excitotoxicity, putatively a major mechanism of ischemic neuronal death, in primary rat retinal cultures. Retinal cultures were prepared from newborn rats (day 1 or 2). Exposure of these cultures (DIV8-10)to NMDA or kainate induced neuronal death. Furthermore, MK-801 or CNQX each partially attenuated glutamateinduced neuronal death, suggesting that both NMDA and kainate receptors mediate it. Thy-1(+) retinal ganglion neurons, like neurons as a whole, were equally injured by NMDA and by kainate. However, GABA(+) or calbindin (+) neurons of the inner nuclear layer were resistant to NMDA, but highly vulnerable to kainate. These neurons may have AMPA/kainate receptors that are highly permeable to Ca2+, as they take up cobalt with kainate stimulation. These results suggest that the AMPA/kainate receptor, rater than the NMDA receptor, may mediate this pattern of selective neurnonal death.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Retinaldeído
/
Maleato de Dizocilpina
/
N-Metilaspartato
/
Morte Celular
/
Cobalto
/
Receptores de Ácido Caínico
/
6-Ciano-7-nitroquinoxalina-2,3-diona
/
Cistos Glanglionares
/
Neurônios Retinianos
/
Neurônios GABAérgicos
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Ophthalmological Society
Ano de publicação:
1997
Tipo de documento:
Artigo