Increased Interleukin-17 Expression in Patients with Idiopathic Inflammatory Myopathies / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
; : 118-122, 2008.
Article
em Ko
| WPRIM
| ID: wpr-55108
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: Idiopathic inflammatory myopathies (IIMs) are systemic autoimmune diseases characterized by infiltration of T lymphocytes, monocytes, and macrophages in muscle tissues. Interleukin-17 (IL-17), a Th17 cytokine, has potent pro-inflammatory actions and plays a role in autoimmune diseases. We investigated the expression of IL-17 in muscle tissues of patients with IIMs. METHODS: We measured the IL-17 mRNA level of muscle tissues from 14 patients with IIMs (9 patients with dermatomyositis and 5 patients with polymyositis) by real-time RT-PCR and compared with controls. We also performed an immunohistochemical stain to detect IL-17 expression. RESULTS: The expressions of IL-17 were significantly enhanced in IIMs than controls. In immunohistochemistry, IL-17 was expressed in perimysial, endomysial and perivascular infiltrating inflammatory cells. CONCLUSION: These results suggest that IL-17 plays a role in the immunopathogenesis of IIMs.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Ko
Revista:
The Journal of the Korean Rheumatism Association
Ano de publicação:
2008
Tipo de documento:
Article