EXPERIMENTAL STUDY OF METABOLIC SUPPORT IN MULTIPLE ORGAN FAILURE / 解放军医学杂志

ABSTRACT

Multiple organ failure (MOF) is a severe complication induced by intra-abdominal sepsis (IAS) in surgical patients. The study was planned to evaluate the role of metabolic support with different formulas of nutrient substants in 42 rabbits of MOF model which was establishei before. The results showed that metabolic support in the early stage of MOF induced by IAS coul increase body weight in varying degree, promote protein synthesis and decrease protein degration in rabbits. Lower non-protein calorie supplied with glucose might decrease stress response, increase nitrogen retention and improve lung function. Overloads of amino acid nitrogen could increase stress response, increase urinary nitrogen excretion and deteriorate the respiratory function.