Effects of RPPS on lymphocyte transformation and NK activity in mice / 中国药理学通报

ABSTRACT

Taking Radix Phodiolae polysac-charides (RPPS) which was extrated from Radix Phodiolae native to Tibet, and using the immunosuppresive mice model, induced with Cy (cyclophosphamide), this paper investigated effects of RPPS on the WBC numbers and Hb content of perpheral blood, thymus weight and cell-mediated immunity of mice. It was found that RPPS had no obvious effects on WBCnumbers and thymus weight, and could decrease the content of Hb in normal mice while it increased the content of Hb in immunosuppresive mice. RPPS not only could enhance lymphocyte transformation and NK activity in normal mice but also could reverse the decrease of the above indexes in immunosuppresive mice. The results suggested that RPPS be a new biological response modifier.