Effects of droperidol on the enhancement of persistent sodium currents induced by in vitro ischemia-like condition in isolated rat CA1 paramidal neurons / 中国临床药理学与治疗学
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-553570
Biblioteca responsável:
WPRO
ABSTRACT
AIM:
To study the effects of droperidol on the enhancement of persistent sodium currents induced by in vitro ischemia-like condition in isolated rat CA1 paramidal neurons.METHODS:
Whole-cell patch-clamp recordings were made from enzymatically isolated rat CA1 hippocampal paramidal neurons. Ischemia was induced by oxygen and glucose deprivation.RESULTS:
All of 3, 10 ,and 30 ?mol?L -1 of droperidol significantly inhibited the enhancement of persistent sodium currents induced by ischemia, but the different concentrations did not show significant difference.CONCLUSION:
Droperidol in clinical concentration can inhibit the enhancement of persistent sodium current induced by ischemia.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Pharmacology and Therapeutics
Ano de publicação:
2000
Tipo de documento:
Artigo