THE RELATIONSHIP BETWEEN ADIPOSE TISSUE DEPOSITION AND DISTRIBUTION AND INSULIN RESISTANCE WITH ENDOTHELIAL FUNCTION IN MIDDLE-AGED SUBJECTS / 解放军医学杂志

ABSTRACT

To investigate the relationship between adipose tissue deposition and distribution and insulin resistance(IR)with endothelial function, the flow mediated endothelium dependent dilatation (EDD), body mass index (BMI), waist circumference (W), waist hip ratio (WHR) and IR index (HOMA IR) were measured, and the relationship of adipose tissue deposition and IR with endothelial dysfunction were analyzed in 527 subjects aged 35～55years without abnormal clinical and laboratory parameters. The results showed that BMI, W, WHR, and HOMA IR in subjects with impaired endothelial function were higher than those with normal one, a high BMI was mainly found in females with obesity, large W and WHR were mainly found in males all groups, and abnormal HOMA IR was found in overweight and obese males and also females in all subgroups. Multiple regression analysis indicated that BMI, WHR and HOMA IR were major factors affecting EDD, though there were gender differences. Both W and EDD were factors involved in IR in both genders. In conclusion, there are close correlations between endothelial function and adipose tissue deposition and distribution and IR