Randomized clinical trial on chemoradiotherapy in locally advanced non small cell lung cancer / 中华放射肿瘤学杂志

ABSTRACT

Objective To evaluate the effect of chemoradiotherapy for stage Ⅲ non small cell lung cancer (NSCLC). Methods From January 1995 to December 2000, 132 patients with stage Ⅲ NSCLC were randomized into two groups radiotherapy alone group (RT, 65 patioents), treated by conventional fractionation to a total dose of D_T 60?Gy～70?Gy/6 w～7 w; Chemoradiotherapy group (CRT, 67 patients), with chemotherapy given concomitantly or alternately with RT for at least 2 courses. Results Complete response rates of RT and CRT group were 14% and 27%, respectively. Disease progression rates of the two groups were 18% and 13%. The 1-,3-and 5-year survival rates were 62.1%, 22.7%, 9.3%and 52.7%, 9.3%, 6.9% in CRT and RT groups(P