Determination method of CYP3A activity and individualization dosage regimen of etoposide / 中国临床药理学与治疗学
Article
em Zh
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| ID: wpr-557404
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WPRO
ABSTRACT
AIM: To explore the correlation between drug concentration of etoposide (VP16) and CYP3A activity (CA) in leukemia. METHODS: The urinary 6?-hydroxycortisol/hydrocortisone ratio is a useful marker for CA. Concentration of VP16 in plasma and CA was determined by HPLC in 20 leucemia patients, and the correlation analysis was performed using the SPSS software. RESULTS: Correlation analysis between drug concentration of VP16 and CA in leukemia was poor correlated (r = 0.725), but concentration of VP16 and lgCA showed a good correlated (r =0.969). CONCLUSION: It is feasible to adjust the therapeutic regimen of VP16 by determining CA.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Clinical Pharmacology and Therapeutics
Ano de publicação:
2004
Tipo de documento:
Article