MMP-2 expression in atherosclerosis plague after injury of carotid intima / 第三军医大学学报

ABSTRACT

Objective To investigate the expression of MMP-2 in rabbit carotid artery injured by airing drying. Methods Fifty-four rabbits were assigned to normal diet (n=18), fat diet (n=36), 18 of fat diet rabbits underwent airing drying of carotid intima after one-week fat diet. Then fed on fat diet after operation. All animals were sacrificed respectively at 1, 2, 3 months after airing drying (n=6 at each time piont), and MMP-2 expression was evaluated by immunohistochemistry. Results MMP-2 expression was low in the carotid of normal diet group, high in the fat diet group including the rabbits underwent airing drying with significant difference between them (P