5-HT receptor subtype-mediated depolarization in guinea pig celiac ganglion neurons / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)2003.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-559455
Biblioteca responsável:
WPRO
ABSTRACT
Aim To identify the serotonin(5-HT)subtype receptor mediated 5-HT-induced depolarization in guinea pig celiac ganglion(CG) neurons.Methods Intracellular recordings were made from the isolated guinea pig CG neurons.Results Cyproheptadine(5-HT_(1/2)antagonist) and BRL 24924(5-HT_(1P) receptor antagonist) reversibly inhibited 5-HT-induced slow depolarization.Whereas,spiperone(5-HT_(1A)receptor antagonist) and mianserin(5-HT_2 receptor antagonist) could not inhibit 5-HT-induced slow depolarization.MDL 72222(5-HT_3 receptor antagonist) could not inhibit 5-HT-induced slow depolarization,but it could reversibly inhibit 5-HT-induced fast depolarization.Pressure ejection of MCPP(5-HT_(1P) receptor agonist) on 5-HT sensitive neurons could induce a slow depolarization which could be inhibited by BRL 24924.Conclusion 5-HT-induced fast and slow depolarization is mediated by 5-HT_3 and 5-HT_(1P) receptor,respectively.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
2003
Tipo de documento:
Artigo