The Effects of Telmisartan on Oxidative stress and the Activity of Protein Kinase C in Type 2 Diabetic Rat / 医学研究杂志

ABSTRACT

Objective To observe the effets of telmisartan on oxidative stress and the activity of protein kinase C in type 2 diabetic Rat.Methods Thirty six Wistar rate were divided into three groups as normal rats、diabetic rats and diabetic rats treated with telmisartan.Blood glucose,blood insulin,blood lipid were measured after 4,5,11 and 17 weeks,serum creatinine,blood uria nitrogen,urinary albumin excretory rate, lipid peroxidation(MDA),the activity of protein kinase C(PKC) and of antioxidant enzymes including Cu/Zn superoxide dismutase(Cu, Zn-SOD),catalase(CAT) and glutathione peroxidase(GSH-Px) in renal tissue were measured after 11 and 17 weeks.In addition,the renal tissue were observed by light microscopy.Results The blood glucose and blood insulin were found no significant difference between that in type 2 diabetic rats with and without telmisartan treatment groups.Comparing with untreated group,the level of blood lipid,serum creatinine,blood uria nitrogen,urinary albumin excretory rate, renal MDA and the activity of cell membrane PKC in telmisartan treated group were significantly decreased,but the activity of renal Cu/Zn SOD,CAT and GSH-Px was increased.There was significant correlation between the change of renal MDA and the activity of antioxidase and the activity of cell membrane PKC. Conclusion Telmisartan could inhibit oxidative stress in diabetic rats, and its mechanism perhaps was decreasing the activity of cell membrane PKC.