Investigation of rat osteoporosis resulting from hyperlipidemia / 中国临床药理学与治疗学

ABSTRACT

AIM: To establish the hyperlipemic rat model by long-term gastric perfusion of intralipid and investigate the effects of hyperlipidemia on bone. METHODS: Eighteen SD rats were randomly divided into control group (C) and high-fat-diet group (HDF), with 9 rats per group. Rats of C group were treated orally with normal saline, and rats in HDF group were oral gavage of intralipid at dose of 5.0 mL/kg, once a day for 20 weeks. At the end of experiment, their serum levels of lipid were measured. Bone histomorphometric analysis of thighbone was performed in undecalcified sections, and the length and width of ulnar were measured. RESULTS: Compared with the C group, serum TC and low density lipoproteins (LDL) were increased (P