Hepatitis B surface antigen terminates codon bias selection / 北京大学学报(医学版)
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-563713
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To investigate the existence condition of hepatitis B surface antigen(HBsAg) termina-tion codon bias.Methods:
A total of 174 reference sequences of all kinds of Hepatitis B virus(HBV) genotypes were chosen from GenBank,and compared by BioEdit.Then secondary structure of RNA was constructed and analyzed together.Results:
(1) There were two types of HBsAg termination codon TAA and TGA in 174 reference sequences.TAA was in 124 cases(71.26%);and TGA in 50 cases(28.74%).(2) There was codon bias selection in HBsAg termination codon,and it could affect the secondary structure of RNA and amino acid sequence encoding protein.Conclusion:
HBsAg termination codon bias exists and may be related to RNA structure and the conservatiom of protein function in the evolutionary progress.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Peking University(Health Sciences)
Ano de publicação:
2004
Tipo de documento:
Artigo