Progress in mechanism of specific immunotherapy / 国际儿科学杂志

ABSTRACT

Specific immunotherapy(SIT)is the most effective therapy for allergies.Although specific immunotherapy has existed for more than 90 years and has made a great progress,its mechanism is not well defined.Early studies focused on the circulating antibodies and effector cells.At present.the research of the mechanism mainly concentrates on the immune therapy on T cells role and a series of cytokines arising from the change,CD4+ regulatory T cells subsets,modified APC induction of immune tolerance,aggregation mechanism of immune effector cells,restructuring allergens under the support of monoclonal antibody technique,allergens DNA vaccines,allergens coupling adjuvants.This essay is a review of progress in mechanism of specific immunotherapy.