The correlation between intestinal mucosa injuries and inflammatory reaction in cancer cachexia mice / 肠外与肠内营养
Parenteral & Enteral Nutrition
; (6)1997.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-565557
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To study the correlation between intestinal mucosa injuries and inflammatory reaction in cancer cachexia mice.Methods:
14 male BALB/c mice were randomized into two groups control group and tumor-bearing group.For tumor-bearing group,a suspension of 10 6 murine colon 26 adenocarcinoma cells was inoculated s.c into each mouse.Non-tumor body weight,intestinal villus height,width,basal layer thickness and muscular layer thickness,TNF-?,IL-1,IL-6,IL-10,IFN-?,sTNF-RⅠand sTNF-RⅡ in the serum and intestinal tissue were determined at the 16th day following the inoculation.Results:
The non-tumor body weight and intestinal villus height and basal layer width in tumor-bearing group were lost significantly as compared with control group.The concentration of serum TNF-?,IL-6,sTNF-RⅠwere higher and the level of serum IL-10 was less in tumor-bearing group.The concentration of intestinal tissue TNF-? was higher but the IL-1,IFN-?,sTNF-RⅠ and sTNF-RⅡ were less in the tumor-bearing group.Conclusion:
The intestinal mucosa injuries have close relation with the inflammatory reactions in cancer cachexia.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Ensaio clínico controlado
Idioma:
Chinês
Revista:
Parenteral & Enteral Nutrition
Ano de publicação:
1997
Tipo de documento:
Artigo