Study on pharmacokinetics of brucine from normal and ultra-micro powder of semen strychni in rats / 中华中医药杂志
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-566713
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To study the pharmacokinetic process ofbrucine from normal and ultra-micro powder ofsemen strychni in rat serum.Methods:
HPLC techniques were used.All pharmacokinetics parameters were calculated with a 3P87 program.Results:
The pharmacokinetics results indicated that the normal powder and the ultra-micro powder ofsemen strychni belonged to two compartment open model.The absorb ofbrucine was just several ten minutes, and there was no obvious difference ofTmax between normal powder and ultra-micro powder.This showed thatBrucine was some material that was easily absorbed.But we can find that Cmax increased from(51.13?0.48)?g/L to(69.26?1.40)?g/L after ultra-micro powder preparation which was quite obvious.K,Ka,B and ? had a obvious increase(P
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Journal of Traditional Chinese Medicine and Pharmacy
Ano de publicação:
2005
Tipo de documento:
Artigo