Interventional effects of natural or chemosynthesis statin on serum NO,ET,hs-CRP,IL-1 and TNF-? in simple essential hypertensive patients / 第三军医大学学报

ABSTRACT

Objective To investigate effect of Xuezhikang capsule (a statin product from Chinese Herbs)or pravastatin (a chemosynthesis statin) combined with antihypertensive drugs on the serum levels of NO,ET,hs-CRP,IL-1 and TNF-? in essential hypertensive (EH) patients.Methods Thirty healthy individuals were enrolled as normal control.One hundred and fifty EH patients admitted in our departments from Dec.2006 to Jun.2008 were enrolled and randomly divided into 3 groups,the antihypertensive drugs treatment group (ATH group,n=50),the pravastatin treatment group (PRA group,n=50) and the Xuezhikang treatment group (XZK group,n=50).Patients in the 3 groups were treated with routine antihypertensive drugs,in addition,pravastatin (20 mg every night) and Xuezhikang (0.6 g/time,twice a day) were given to PRA group and XZK group respectively.Serum NO,ET,hs-CRP,IL-1 and TNF-? were detected before and after eight-week treatment.Results Compared with healthy individuals,serum NO was decreased (P