Clinical significance of genetics and epigenetic aberrance in myelodysplastic syndromes / 中国实用内科杂志
Chinese Journal of Practical Internal Medicine
; (12)2001.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-567484
Biblioteca responsável:
WPRO
ABSTRACT
Myelodysplastic syndromes (MDS) is one of clonal disorders of hematopoietic stem cells.Cytogenetic,molecular genetic and epigenetic aberrances are critical to diagnosis,prognosis and treatment of MDS.5q-,-7/7q-and 20q-are the most frequent cytogenetic aberrance in MDS.Fusion genes,genetic mutation and deletion are the most important mechanisms for every subtype of MDS.Aberrant methylation plays an essential role in both initial and secondary MDS.All these aberrances are very significant for the development and transformation of MDS.Genetic and epigenetic alterations are new targets for MDS diagnosis and treatment.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Practical Internal Medicine
Ano de publicação:
2001
Tipo de documento:
Artigo