ATROPHY OF THE SPLEEN COMPLICATED WITH OVERWHELMING FNEUMOCOCCAL BACTEREMIA / 重庆医科大学学报

ABSTRACT

The authors reported a case of overwhelming pneumococcal infection in a hypo-splenic adult.The patient was treated with ten million units of aqueous penicilling G.but there was no effect.He died 28 hours after admission.Streptococcus pneumo-niae was isolated from the blood culture.Autopsy was performed 6 hours after death. The spleen was found to be atropluc and the weight was 100g. Bilateral adrenal hemorrhagic necrosis was found. Microscopic examination demonstrated evidence of p-urulent pneumonia, meningitis, disseminated intravascular coagulation and Waterhouse-Friderichsen syndrome.The pathogenetic mechanism,early detection and prevention a-re discussed