Protective Effects of Ginkgo (Ginkgo biloba) Extracts on Acute Ischemia in Brains / 中草药

ABSTRACT

Protective effects of Ginkgo biloba extract (GBE) on ischemia in rat and mice brain were studided. The ischemia model in brains was prepared by occlusion of bilateral carotid arteries and vertebra arteries in rat. The results demonstrated that GBE had no effect on electroencephalogram (EEG) of 5 min of ischemia, but it promoted the recovery of EEG during reperfusion. When it was reperfushed for 10 min,amplitude of EEG in the control group only recovered from 17. 2% after ischemia to 46. 6% of normal level. While 0. 2g/kg GBE has a recovery of 93% from normal level. At 4. 0g/kg GBE the life-span of mice with bilateral ligated carotid arteries was significantly lengthened. The above results proved that GBE has some protective effect on anoxia caused by acute ischemia in rat and mouse brain.