A novel antiapoptosis gene,survivin,expression in bladder transitional cell cancer / 重庆医科大学学报
Journal of Chongqing Medical University
; (12)1987.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-571874
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To study the expression of a novel inhibitor gene of apoptosis,survivin,in bladder transitional cell cancer,and its relationship with the expression of p53,bcl-2 and ki67 genes.Methods:
Using streptavidin-biotin peroxidase(SP) method,we examined the expression of survivin,p53,bcl-2 and ki67 proteins in 10 normal bladder tissues and 58 bladder transitional cell cancer tissues.Results:
Survivin was expressed in 41 of 58(70.7%) cases of BTCC.In contrast,normal bladder epithelium did not express survivin.Overexpression of survivin was related to the tumor grade and clinical stage.The expression of survivin was strongly correlated with p53.bcl-2 and ki67 expression.Conclusion:
Apoptosis inhibition by survivin, alone or in cooperation with p53 and bcl-2 may participate in the onset and progression of bladder transitional cell cancer.Survivin could be a new diagnostic/therapeutic target in bladder tranditional cell cancer.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Chongqing Medical University
Ano de publicação:
1987
Tipo de documento:
Artigo