The effects of serotomin on ionic channels currents and membrane potentials of the guinea pig proximate colon myocytes / 中华消化杂志

ABSTRACT

Objective To investigate the effects of serotonin(5-HT) on the ionic channels currents and membrane potentials of single guinea pig proximate colon myocytes. Methods Cell images before and after contraction were captured and analyzed with an imag e analysis software. Channels currents, action potential (AP) and resting potent ial (RP) were recorded with an EPC-9 amplifier. Results The direct actions of 10 ?mol/L 5-HT to myocytes resulted in followin g effects Firstly, the exogenous stimulated peak values of AP reduced to 60%?7 .3%(n=7,P