The renal protective effects of ulinastatin in rats with multiple organ dysfunction syndrome / 中华急诊医学杂志

ABSTRACT

Objective To study the renal protective effects of ulinastatin in rats with multiple organ dysfunction syndrome(MODS). Methods Thirty-six Wistar rats were divided into 3 groupscontrol group ,model group and treatment group. The MODS models were produced by injecting lipopolysaccharide(LPS) through the sublingual vein into the rats. Ulinastatin was injected into the sublingual vein of the rats in treatment group, LPS was injected into rats in the same way after 10 minutes. On the second hour and the sixth hour after treatment, serum and renal tissue samples were collected from the rats to determine the level of TNF-?,IL-6, IL-1?, iNOS by RIA.The pathologic changes of renal tissue was examined. Results The levels of TNF-?,IL-6, IL-1?, iNOS of serum and renal tissue in treatment group were obviously lower than in model group (P