Inhibitory Effect of Acanthopanax Senticosus Saponin on the Expression of Vascular Endothelial Growth Factor in Human HepG_2 Cell Line / 中药新药与临床药理

ABSTRACT

Objective To investigate the effect of Acanthopanax senticosus saponin (ASS)on the protein and mRNA expression of vascular endothelial growth factor (VEGF) in human HepG2. Methods HepG2 were incubated with ASS,the expression of VEGF was detected by ELISA assay,and the mRNA expression of VEGF was detected by RT-PCR assay. Results ASS (250,500 ?g/mL) decreased the expression of VEGF protein and VEGF mRNA (P