Study on the Relative Bioavailability of Micro-emulsified Genistein in Rabbits / 中药新药与临床药理
Article
em Zh
| WPRIM
| ID: wpr-578389
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WPRO
ABSTRACT
Objective To study the pharmacokinetics and the relative bioavailabi lity of micro-emulsified genistein in rabbits. Methods Rabbits received gastric gavage of micro-emulsified genistein and CMC-Na suspension of genistein. Then the genistein content in rabbit plasma at different time was determined by HPLC ,concentration-time curve was drafted,and the pharmacokinetic parameters and the relative bioavailability were calculated. Results The main parameters of mic ro-emulsified genistein and CMC-Na suspension of genistein were as follows:AU C0→10h being(24.90?1.24)and(10.71?0.86)?g?h?mL-1,Cmax being(4.02?0.20)a nd(0.99?0.04)?g?mL-1,Tmax being 2 h and 4 h,respectively. The relative bio availability of micro-emulsified genistein was 232.49 %. Conclusion Micro-emu lsified genistein system can improve the bioavailability of genistein evidently.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Traditional Chinese Drug Research & Clinical Pharmacology
Ano de publicação:
1993
Tipo de documento:
Article