Pharmacological effects of Gushudan against osteoporosis / 中草药

ABSTRACT

Objective To investigate the preventive effects of Gushudan on osteoporosis in rats after administrated prednisolone.Methods Wistar male rats(60) were divided into six groups control group,model group,Gushudan groups(3,1,and 0.3 g/kg),and Gushukang 1 g/kg group.The effect was observed by measuring the levels of blood calcium,blood phosphorus,blood BGP content,bone calcium,bone phosphorus,bone density,and hone biomechanics.Results After eight weeks,Gushudan significantly increased the bone density,bone biomechanics,blood BGP content,bone calcium,and bone phosphorus in model group rats.Conclusion Gushudan could increase bone density,bone biomechanics,blood BGP content,bone calcium,and bone phosphorus induced by prednisolone.These results suggest that Gushudan has a distinct preventive effect on osteoporosis rats.