Clinical features analysis of death cases of hepatic failure induced by viral hepatitis / 重庆医科大学学报

ABSTRACT

Objective:To analyze the cause of patients with hepatic failure induced by viral hepatitis to provide guidance for the clinical treatment. Methods:Retrospective analysis was adopted to study the clinical data of 115 patients died of hepatic failure induced by viral hepatitis enrolled in our department for five years.The data of each case was collected from the check of final diagnosis and the last check before death. Results:Of all 115 patients,103 cases were male,12 cases were female. with an average age of 45.7 years.There were 89 cases with chronic severe hepatitis,20 cases with cirrhosis.114 cases infected hepatitic B virus including 12 cases with superfection of HAV,HDV,HEV.Of 110 cases,24 were HBeAg positive24/ 110,21.8%),61 were HBeAb positive(61/110,55.5%). Of 85 cases,HBV DNA quantity of 68 cases was more than 1?105 copies/m(l68/85,80%),HBV DNA quantity of 17 cases was less than 1?10(517/85,20%).TBil,PTA and ALT at admission were 403.17 ?219.43,38.33 ?19.14 and 496.78 ?801.56 respectives,while those at death were 478.03 ?234.89,32.39 ? 16.54,218.04?426.58 respectively.Severe complications presented. Conclusion:In our country,hepatic failure was mainly induced by chronic severe hepatitis and cirrhosis infected with hepatitis B virus. The active replication of HBV DNA and the viral mutation could be causes of the development of disease. As the incidence rate of complications is high,preventing complication is necessary to reduce fatality rate of the patients with hepatic failure.