Effects of acidosis on cardiac hemodynamics in aged rat heart after reperfusion injury / 重庆医科大学学报

ABSTRACT

Objective:To observe the effects of prolonged transient acidosis on cardiac hemodynamics in aged rat heart after reperfusion injury.Methods:60 isolated SD rats hearts(≥18 months)perfused by Langendorff were randomly divided into 6 groups(n=10)(1)normal contro1(C)group;(2)reperfusion injury(I/R)group;(3)ischemic postconditioning(IPO)group;(4)acidosis(H+)group;(5)postconditioning+alkalotic(IPO+OH-)group;(6)alkalotic(OH-)group.The direct effects of prolonged transient acidosis on myocardiac contractility were observed by a langendorff apparatus through the hemodynamics parameters including heart rate(HR),left ventricular systolic pressure(LVSP),left ventricular end-diastolic pressure(LVEDP),and ?dp/dtmax.Results:The LVEDP were increased and HR,LVSP,?dp/dtmax were decreased in I/R group,IPO group,H+ group,IPO+OH-group and OH-group compared with those in C group(P