Preparation of sustained-release dropping pills of total glucosides in Radix Paeoniae Alba / 中草药

ABSTRACT

Objective To optimize the formulation in preparation of dropping pills with total glucosides in Radix Paeoniae Alba and evaluate its accumulative release percentage in vitro.Methods With the hardness,roundness,and adhesion as the evaluation,orthogonal design was conducted.With dissolution rate of 12 h as the indices,according to the uniform design,the optimum coating formulation of Eudragit RL and RS was established.Results The dropping pills met the criterion of formulation,and the preparation release met the characteristics of the sustained release of the first order kinetics.Conclusion The optimal formulation is simple,which provides the basis for further development of new preparations of total glucosides in Radix Paeoniae Alba.