The stability study of superparamagnetic iron oxide nanoparticles modified by dextran / 重庆医科大学学报

ABSTRACT

Objective:To study the stability of Superparamagnetic iron oxide(SPIO) nanoparticles modified by dextran prepared by coprecipitation.Methods:To evaluate its stability through compared the characteristic parameters which contained the character,pH,iron content,size,saturated magnetization and T2 relaxivity before and after the strengthen experimentation and the long-term experimentation.All that was carried according to the basic request of injection requirements.Results:The above characteristic parameters had no statistic differences between before experimentation and after experimentation.Conclusion:The research showed that SPIO made by coprecipitation had good stability,can be further used as the contrast media of magnetic resonance imaging and target gene carrier.