Quality Evaluation of Clinical Literature on Chinese Medicinal Therapies of Post-Stroke Depression / 中国中医药信息杂志

ABSTRACT

Objective To access the effectiveness and safety of traditional Chinese medicine for the patients with post-stroke depression,and provide the evidence for clinical practice.Methods Systematically search(computer and hand) CNKI,VIP,CBM,PUBMED,EMBASE and related magzines for the randomized controlled trials(RCT) and clinical controlled trials(CCT) of traditional Chinese medicine in treating post-stroke depression published.To evaluate and analyze the quality of literature with evidence-based medicine approach.Results 69 RCTs and 6 CCTs met the selection criteria.Only 11 RCTs had proper random methods and 2 RCTs used blind method.There were coparability of groups in 62 RCTs and it was mentioned in 8 researchs of exit and lost.It was showed that the effective rate of treatment group was higher than that of the control group,the ineffective rate and adverse effects in treatment group were lower than that of the control group.4 RCTs were made Meta analysis and quantitative analysis.4 trials were 3 using Jadad Scale,11 trials were 2,other 55 trials were 0～1.Conclusions Large sample,multicentre,prospective randomized trials are needed to strengthen Meta analysis evidence concluded by lower methodological quality of included studies.Furthermore,systematic review should be improved and updated if new evidence appeared.