Clinic study on treatment of cardiac arrhythmia by fastigial nucleus stimulation / 重庆医科大学学报

ABSTRACT

Objective:To study the curative effect and reliability of fastigial nucleus stimulation (FNS)in treating nonmalignant arrhythmia. Methods:In a random period,FNS was used to treat 45 patients,who consulted doctors for repetitive palpitation,had cardiac arrhythmia (supraventricular premature beats,supraventricular runs,ventricular premature beats)confirmed by 24 h Holter monitoring electrocardiogram,and whose state of illness did not improve after being treated by one or several antiarrhythmic drugs. After those patients were treated by FNS 40 minutes a time,two times a week,for 15 times,the changes of 24 h Holter monitoring electrocardiogram were observed. Results:Before and after treatment by FNS,the numbers of SVPB were (3 358.5?5 044.0)/24 h and (1 142.8?2 722.3)/24 h respectively;those ofVPBwere(10 469.7?9 464.9)/24 h and(4 379.4?8 143.3)/24 h respectively;normalized low frequencies(LFnorm)were(35.28?7.04)nU and(31.82?7.35)nU respectively;normalized high frequencies(HFnorm)were (24.32?4.18)nU and (26.84?4.66)nU respectively. LF/HF was 1.47?0.32 and 1.21?0.29 respectively. The differences between pre-treatment and post-treatment indices were all statistically significant (P