Integron-mediated multidrug resistance in clinical multi-reisistant Pseudomonas aeruginosa / 中华检验医学杂志
Chinese Journal of Laboratory Medicine
; (12)2003.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-585002
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the action of integron-mediated multidrug resistance in clinical multi-resistant Pseudomonas aeruginosa.Methods The strains of multi-resistant Pseudomonas aeruginosa were selected with K-B susceptibility method. The three-dimensional method was taken to differentiate the various beta-lactamases. The integron was determined by PCR with integron-specific primer. DNA sequencing was also used to analyze resistance-related gene in the integron in multi-resistant Pseudomonas aeruginosa.Results The positive rate of integron detection in multi-resistant Pseudomonas aeruginosa was 42.4%.Three kinds of different length integron were found .They were 750bp,1 000bp and 2 500bp and aadB,aadA2,aadB,aac6-II and PSE-1 were the resistance-related gene cassette in the integrons.Conclusions Integron took part in mutiple resistance in multi-resistant Pseudomonas aeruginosa.We should pay more attention to integron-mediated horizontal transference of mulidurg resistance to lessen the occurrence of multi-resistant strains.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Laboratory Medicine
Ano de publicação:
2003
Tipo de documento:
Artigo